Now showing 1 - 4 of 4
  • Publication
    Metadata only
    Increased type-I interferon level is associated with liver damage and fibrosis in primary sclerosing cholangitis
    (2024)
    Salzmann, Rebekka J.S. 
    ;
    Krötz, Christina 
    ;
    Mocan, Tudor 
    ;
    Mocan, Lavinia P. 
    ;
    Grapa, Cristiana 
    ;
    Rottmann, Sophia 
    ;
    Reichelt, Ramona 
    ;
    Keller, Cindy M. 
    ;
    Langhans, Bettina 
    ;
    ; ; ; ;
    Krawczyk, Marcin 
    ;
    Milkiewicz, Piotr 
    ;
    Sparchez, Zeno 
    ;
    Lammert, Frank 
    ;
    ;
    Gonzalez-Carmona, Maria A. 
    ;
    Willms, Arnulf 
    ;
    Strassburg, Christian P. 
    ;
    Kornek, Miroslaw T. 
    ;
    Dold, Leona 
    ;
    Lukacs-Kornek, Veronika 
    Background: The level of type-I interferons (IFNs) in primary sclerosing cholangitis (PSC) was investigated to evaluate its association with disease activity and progression. Methods: Bioactive type-I IFNs were evaluated in a murine model of PSC and human patients’ sera using a cell-based reporter assay and ELISA techniques. In total, 57 healthy participants, 71 PSC, and 38 patients with primary biliary cholangitis were enrolled in this study. Results: Bioactive type-I IFNs were elevated in the liver and serum of multidrug resistance protein 2–deficient animals and showed a correlation with the presence of CD45+ immune cells and serum alanine transaminase levels. Concordantly, bioactive type-I IFNs were elevated in the sera of patients with PSC as compared to healthy controls (sensitivity of 84.51%, specificity of 63.16%, and AUROC value of 0.8267). Bioactive IFNs highly correlated with alkaline phosphatase (r=0.4179, p<0.001), alanine transaminase (r=0.4704, p<0.0001), and gamma-glutamyl transpeptidase activities (r=0.6629, p<0.0001) but not with serum bilirubin. In addition, patients with PSC with advanced fibrosis demonstrated significantly higher type-I IFN values. Among the type-I IFN subtypes IFNα, β and IFNω could be detected in patients with PSC with IFNω showing the highest concentration among the subtypes and being the most abundant among patients with PSC. Conclusions: The selectively elevated bioactive type-I IFNs specifically the dominating IFNω could suggest a novel inflammatory pathway that might also have a hitherto unrecognized role in the pathomechanism of PSC.
      37
  • Publication
    Metadata only
    The Impact of Vegan and Vegetarian Diets on Physical Performance and Molecular Signaling in Skeletal Muscle
    Muscular adaptations can be triggered by exercise and diet. As vegan and vegetarian diets differ in nutrient composition compared to an omnivorous diet, a change in dietary regimen might alter physiological responses to physical exercise and influence physical performance. Mitochondria abundance, muscle capillary density, hemoglobin concentration, endothelial function, functional heart morphology and availability of carbohydrates affect endurance performance and can be influenced by diet. Based on these factors, a vegan and vegetarian diet possesses potentially advantageous properties for endurance performance. Properties of the contractile elements, muscle protein synthesis, the neuromuscular system and phosphagen availability affect strength performance and can also be influenced by diet. However, a vegan and vegetarian diet possesses potentially disadvantageous properties for strength performance. Current research has failed to demonstrate consistent differences of performance between diets but a trend towards improved performance after vegetarian and vegan diets for both endurance and strength exercise has been shown. Importantly, diet alters molecular signaling via leucine, creatine, DHA and EPA that directly modulates skeletal muscle adaptation. By changing the gut microbiome, diet can modulate signaling through the production of SFCA.
      5
  • Publication
    Metadata only
    The Effects of the New Training Concept ‘Slidation’ on Postural Control in Pediatric Cancer and Hematologic Patients
    (2018)
    Kurpiers, N. 
    ;
    Worbs, T. 
    ;
    Lindkamp, K. 
    ;
    Schwier, T. 
    ;
    Nieder, A. 
    ;
    ;
    Vogler, Tim 
    ;
    Krauth, K. 
      3
  • Publication
    Metadata only
    The Importance of Directly Derived Information in the Basketball Jump Shot
    (2017) ;
    Böker, Markus 
    ;
    Hennig, Linda 
    ;
    Heinen, Thomas 
      2